Chloroacetyl chloride → HCID 13769980, compound

HRID 542710Notes

Reaction equation

HRID 542710 reaction equation
[Cl:1][CH2:2][C:3](Cl)=[O:4].C(N(CC)CC)C.[S:13]1[C:22]2[C:21](=[O:23])[NH:20][C:19]3[CH:24]=[CH:25][CH:26]=[N:27][C:18]=3[NH:17][C:16]=2[CH:15]=[CH:14]1>O1CCOCC1>[Cl:1][CH2:2][C:3]([N:17]1[C:16]2[CH:15]=[CH:14][S:13][C:22]=2[C:21](=[O:23])[NH:20][C:19]2[CH:24]=[CH:25][CH:26]=[N:27][C:18]1=2)=[O:4]

Participants

5

Reactant 3

HCID 6577Chloroacetyl chlorideHCID 8471TriethylamineHCID 13769978HCID 13769978, compound

Product 1

HCID 13769980HCID 13769980, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Chloroacetyl chloride (1.9 ml) is added in 20 minutes, contemporaneously with triethylamine (3.4 ml), to a suspension of 4,9-dihydro-10H-pyrido[3,2-b]thieno[3,2-e][1,4]-diazepin-10-one (4.4 g) in dioxane (200 ml), heated to reflux.

Workup

  1. temperatureheated to reflux

Sources & evidence

ORD record
ord-ecaf327baa9145f0a57716ea68f35666
Source dataset
uspto-grants-1987_04
Patent number
US04659707

Reaction notes

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