反应详情

A mixture of 7-fluoro-1-methyl-3-(1-methyl-1H-tetrazol-5-yl)-4-quinolone (0.2 g) and piperidine (5 ml) was heated on a steam bath for 22 hours. The mixture was cooled and the solid product was collected and recrystallised from industrial methylated spirit to give the novel compound 1-methyl-3-(1-methyl-1H-tetrazol-5-yl)-7-piperidino-4-quinolone, m.p. 180°-183°.

1. temperaturewas heated on a steam bath for 22 hours
2. temperatureThe mixture was cooled
3. customthe solid product was collected
4. customrecrystallised from industrial methylated spirit