Piperidine → 1-methyl-3-(1-methyl-1H-tetrazol-5-yl)-7-piperidino-4-quinolone

HRID 542821Notes

Reaction equation

HRID 542821 reaction equation
F[C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:19])[C:7]([C:13]3[N:17]([CH3:18])[N:16]=[N:15][N:14]=3)=[CH:8][N:9]2[CH3:12])=[CH:4][CH:3]=1.[NH:20]1[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1>>[CH3:12][N:9]1[C:10]2[C:5](=[CH:4][CH:3]=[C:2]([N:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)[CH:11]=2)[C:6](=[O:19])[C:7]([C:13]2[N:17]([CH3:18])[N:16]=[N:15][N:14]=2)=[CH:8]1

Participants

3

Reactant 2

HCID 8082PiperidineHCID 134744537-fluoro-1-methyl-3-(1-methyl-1H-tetrazol-5-yl)-4-quinolone

Product 1

HCID 134744311-methyl-3-(1-methyl-1H-tetrazol-5-yl)-7-piperidino-4-quinolone

Procedure

A mixture of 7-fluoro-1-methyl-3-(1-methyl-1H-tetrazol-5-yl)-4-quinolone (0.2 g) and piperidine (5 ml) was heated on a steam bath for 22 hours. The mixture was cooled and the solid product was collected and recrystallised from industrial methylated spirit to give the novel compound 1-methyl-3-(1-methyl-1H-tetrazol-5-yl)-7-piperidino-4-quinolone, m.p. 180°-183°.

Workup

  1. temperaturewas heated on a steam bath for 22 hours
  2. temperatureThe mixture was cooled
  3. customthe solid product was collected
  4. customrecrystallised from industrial methylated spirit

Sources & evidence

ORD record
ord-a57b66c102c341d0b4434e2b4dfb88c2
Source dataset
uspto-grants-1987_04
Patent number
US04659718

Reaction notes

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