Pyrrolidine → 1-methyl-3-(1-methyl-1H-tetrazol-5-yl)-7-pyrrolidino-4-quinolone

HRID 542823노트

반응식

HRID 542823 반응식
F[C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:19])[C:7]([C:13]3[N:17]([CH3:18])[N:16]=[N:15][N:14]=3)=[CH:8][N:9]2[CH3:12])=[CH:4][CH:3]=1.[NH:20]1[CH2:24][CH2:23][CH2:22][CH2:21]1>>[CH3:12][N:9]1[C:10]2[C:5](=[CH:4][CH:3]=[C:2]([N:20]3[CH2:24][CH2:23][CH2:22][CH2:21]3)[CH:11]=2)[C:6](=[O:19])[C:7]([C:13]2[N:17]([CH3:18])[N:16]=[N:15][N:14]=2)=[CH:8]1

참가 물질

3

반응물 2

HCID 31268PyrrolidineHCID 134744537-fluoro-1-methyl-3-(1-methyl-1H-tetrazol-5-yl)-4-quinolone

생성물 1

HCID 134744321-methyl-3-(1-methyl-1H-tetrazol-5-yl)-7-pyrrolidino-4-quinolone

실험 절차

In a similar way to that described in Example 30, 7-fluoro-1-methyl-3-(1-methyl-1H-tetrazol-5-yl)-4-quinolone (5 g) was boiled under reflux with pyrrolidine (50 ml) for 20 hours to give 1-methyl-3-(1-methyl-1H-tetrazol-5-yl)-7-pyrrolidino-4-quinolone, m.p. 267°-270° (from industrial methylated spirit:water 5:1).

출처 및 근거

ORD 기록
ord-31e07a661a0e474dafa0cd89e6078070
출처 데이터셋
uspto-grants-1987_04
특허 번호
US04659718

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