反应详情

A mixture of 5.5 g (0.015 mole) of 6-bromo-N-(6-methoxy-4-methyl-8-quinolinyl)hexanamide and 1.8 g (0.018 mole) of N-methylpiperazine in 70 ml of benzene was heated under reflux for 20 hr, treated with 2 ml of triethylamine, and heated for an additional 24 hr. The mixture was allowed to cool, filtered and the filtrate was washed with water, dried and concentrated to dryness in vacuo. The residue was recrystallized twice from n-hexane containing a little toluene and then dried in vacuo at 68° to afford 3.1 g (53%) of the title compound, mp 104°-107°.

1. temperaturewas heated
2. temperatureunder reflux for 20 hr
3. temperatureheated for an additional 24 hr
4. temperatureto cool
5. filtrationfiltered
6. washthe filtrate was washed with water
7. customdried
8. concentrationconcentrated to dryness in vacuo
9. customThe residue was recrystallized twice from n-hexane containing a little toluene
10. customdried in vacuo at 68°