反应详情

A solution of 2-aminothiazole (0.5 g) and 2-ethoxy-1,1-bis(phenylsulphonyl)ethene (1.76 g) in dimethylacetamide (20 ml) was heated at reflux for 3.5 hours. The solution was cooled and poured onto ice (200 g) and then the resulting buff precipitate was filtered off, washed with water and dried in vacuo over phosphorous pentoxide. Recrystallisation from ethyl acetate gave 1,1-bis(phenylsulphonyl)-2-(thiazol-2-ylamino)ethene (0.9 g), m.p. 189°-191° C.

1. temperatureat reflux for 3.5 hours
2. temperatureThe solution was cooled
3. additionpoured onto ice (200 g)
4. filtrationthe resulting buff precipitate was filtered off
5. washwashed with water
6. dry with materialdried in vacuo over phosphorous pentoxide
7. customRecrystallisation from ethyl acetate