反应详情

温度

10 °C

A solution (cooled to 10° C.) of 18.1 g. of 4-amino-3,5-dimethoxy-benzaldehyde in 210 ml. of 98% formic acid was treated dropwise with 70 ml. of acetic anhydride with stirring and the temperature was maintained below 15° C. The solution was then stirred for 2 hours at room temperature, treated with 80 ml. of water and evaporated to dryness under vaccum. The residue was washed with water, recrystallized from alcohol and there was obtained 2',6'-dimethoxy-4'-formyl-formanilide having a melting point of 159°-160° C.

1. temperaturethe temperature was maintained below 15° C
2. additiontreated with 80 ml
3. customof water and evaporated to dryness under vaccum
4. washThe residue was washed with water
5. customrecrystallized from alcohol