Benzenamine, 3,5-bis(trifluoromethyl)- → HCID 18607495, compound

HRID 543359Notes

Reaction equation

HRID 543359 reaction equation
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:4]=[C:5]([CH:7]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:9]=1)[NH2:6].[C@@H:16]12[C:25](=[O:26])[O:24][C:22](=[O:23])[C@@H:17]1[CH2:18][CH2:19][CH2:20][CH2:21]2>C(OC(C)C)(C)C>[F:1][C:2]([F:14])([F:15])[C:3]1[CH:4]=[C:5]([NH:6][C:25]([C@H:16]2[CH2:21][CH2:20][CH2:19][CH2:18][C@H:17]2[C:22]([OH:24])=[O:23])=[O:26])[CH:7]=[C:8]([C:10]([F:11])([F:12])[F:13])[CH:9]=1

Participants

4

Reactant 2

HCID 9480Benzenamine, 3,5-bis(trifluoromethyl)-HCID 641660Hexahydrophthalic anhydride, cis-

Product 1

HCID 18607495HCID 18607495, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 7914Diisopropyl EtherSolvent

Procedure

A mixture of 2.3 g (0.01 mole) of 3,5-bistrifluoromethyl aniline and 1.5 g (0.01 mole) of cis-cyclohexane-1,2-dicarboxylic anhydride was stirred in iso-propyl ether at room temperature. The precipitated crystals were filtered off to give 3.0 g of the title compound.

Workup

  1. filtrationThe precipitated crystals were filtered off

Sources & evidence

ORD record
ord-6afe515937a446a8807f4c2b08e1be3d
Source dataset
uspto-grants-1987_04
Patent number
US04661630

Reaction notes

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