HCID 13210257, compound → HCID 10402160, compound

HRID 543375Notes

Reaction equation

HRID 543375 reaction equation
[Cl:1]CC([NH:5][CH2:6][C:7]1[CH:12]=[C:11]([C:13]([CH3:16])([CH3:15])[CH3:14])[CH:10]=[C:9]([S:17]([CH3:20])(=[O:19])=[O:18])[C:8]=1[OH:21])=O>Cl.C(O)C>[ClH:1].[NH2:5][CH2:6][C:7]1[CH:12]=[C:11]([C:13]([CH3:14])([CH3:15])[CH3:16])[CH:10]=[C:9]([S:17]([CH3:20])(=[O:18])=[O:19])[C:8]=1[OH:21]

Participants

4

Reactant 1

HCID 13210257HCID 13210257, compound

Product 1

HCID 10402160HCID 10402160, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 702EthanolSolvent

Procedure

6.3 g (0.028 mol) of 2-chloro-N-[5-(1,1-dimethylethyl)-2-hydroxy-3-methylsulfonylbenzyl]acetamide in a mixture of 20 ml of concentrated hydrochloric acid and 40 ml of ethanol are boiled under reflux for 16 hours. The precipitated product is filtered off with suction and recrystallized from ethanol.

Workup

  1. temperatureunder reflux for 16 hours
  2. filtrationThe precipitated product is filtered off with suction
  3. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-0eec8b5262444e9e87f286f134e53400
Source dataset
uspto-grants-1987_04
Patent number
US04661636

Reaction notes

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