Hydrochloric Acid → HCID 131713501, compound

HRID 543508Notes

Reaction equation

HRID 543508 reaction equation
[F:1][CH2:2][C:3]([NH:20]C(OC(C)(C)C)=O)([CH2:8][C:9](=[CH2:19])[CH2:10][NH:11]C(OC(C)(C)C)=O)[C:4]([O:6][CH3:7])=[O:5].[ClH:28]>CCOCC>[ClH:28].[ClH:28].[F:1][CH2:2][C:3]([NH2:20])([CH2:8][C:9](=[CH2:19])[CH2:10][NH2:11])[C:4]([O:6][CH3:7])=[O:5]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20461679HCID 20461679, compound

Product 1

HCID 131713501HCID 131713501, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Methyl 2-fluoromethyl-2,5-di(tert-butoxycarbonylamino)-4-methylene pentanoate (0.72 g) obtained in Step C above is treated with dry ether saturated with HCl gas. After stirring overnight the title compound is collected (0.38 g, 78%). Recrystallisation from isopropanol/ethyl acetate gives the pure product yield 300 mg.

Sources & evidence

ORD record
ord-42643367b62d441a9b55c6223cb4a339
Source dataset
uspto-grants-1984_05
Patent number
US04446151

Reaction notes

Loading…