Ethanol → Diethyl methyl(3-methylbut-2-en-1-yl)propanedioate
Reaction equation
[Na].[CH2:2]([O:4][C:5](=[O:13])[CH:6]([CH3:12])[C:7]([O:9][CH2:10][CH3:11])=[O:8])[CH3:3].[CH3:14][C:15]([CH3:19])=[CH:16]CBr.[CH2:20](O)C>>[CH2:2]([O:4][C:5](=[O:13])[C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])([CH3:20])[CH2:12][CH:14]=[C:15]([CH3:19])[CH3:16])[CH3:3]Participants
Conditions
- Temperature
- 60 °C
Procedure
36.1 g of sodium (cut into small pieces) was introduced into a three-necked flask equipped with reflux condenser, dropping funnel, and agitator. To this mixture was added 800 ml of absolute ethanol so quickly that the solution continued to boil vigorously. The hot alcoholate solution was combined dropwise with 269.6 g of freshly distilled methylmalonic acid diethyl ester, the mixture was stirred for 1/2 hour at 60° C. and then 241.7 g of dimethylallyl bromide was also added dropwise thereto. After one hour of agitation under heating, the thus-precipitated sodium bromide was filtered off, the precipitate was washed, and the filtrate was concentrated. The remainder was taken up in ether, washed neutral with saturated sodium chloride solution, dried over magnesium sulfate, and concentrated on a forced circulation evaporator. The evaporation residue was fractionated on an oil pump, yielding 266 g of the title compound, bp7 97°-112° C.
Workup
- customequipped
- temperaturewith reflux condenser
- temperatureAfter one hour of agitation under heating
- filtrationthe thus-precipitated sodium bromide was filtered off
- washthe precipitate was washed
- concentrationthe filtrate was concentrated
- washwashed neutral with saturated sodium chloride solution
- dry with materialdried over magnesium sulfate
- concentrationconcentrated on a forced circulation evaporator
Sources & evidence
- ORD record
- ord-f30a2c6d3e5a47a78869c045394f6054
- Source dataset
- uspto-grants-1984_05
- Patent number
- US04446147
Reaction notes
Loading…