Hydrochloric Acid → HCID 20460474, compound

HRID 543719Notes

Reaction equation

HRID 543719 reaction equation
[Br:1][CH2:2][C:3](Cl)=[O:4].[CH:6]1[C:16]2[C:15](=[O:17])[NH:14][C:13]3[CH:18]=[CH:19][CH:20]=[CH:21][C:12]=3[NH:11][C:10]=2[CH:9]=[CH:8][CH:7]=1.Cl>C1(C)C=CC=CC=1>[Br:1][CH2:2][C:3]([N:11]1[C:10]2[CH:9]=[CH:8][CH:7]=[CH:6][C:16]=2[C:15](=[O:17])[NH:14][C:13]2[CH:18]=[CH:19][CH:20]=[CH:21][C:12]1=2)=[O:4]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 89602Bromoacetyl chlorideHCID 2013275,10-Dihydro-11H-dibenzo(b,e)(1,4)diazepin-11-one

Product 1

HCID 20460474HCID 20460474, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

93 g (0.55 mol) of bromoacetyl chloride were added dropwise, with stirring, to a suspension of 105 g (0.5 mol) of 5,10-dihydro-11H-dibenzo[b,e][1,4]-diazepin-11-one in 1 liter of toluene, at 90° C. The mixture was then refluxed for a further 30 minutes, during which there was a strong development of hydrogen chloride. After cooling, the dark blue crystal slurry obtained was suction filtered;

Workup

  1. temperatureThe mixture was then refluxed for a further 30 minutes, during which there
  2. temperatureAfter cooling
  3. customthe dark blue crystal slurry obtained
  4. filtrationfiltered

Sources & evidence

ORD record
ord-acd7c0985d66456cb317a36ac453a068
Source dataset
uspto-grants-1984_05
Patent number
US04447434

Reaction notes

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