反应详情

3,4-Dimethoxyphenethylamine (14.4 g) and p-toluidinoacetic acid (13.1 g) were heated for 1.5 hours at 190° C. in a stream of nitrogen. After cooling, the reaction mixture was dissolved in ethyl acetate and the solution was washed with a cooled 1 N sodium hydroxide solution and water and then dried. The solvent was distilled off and the oily residue was crystallized by adding ether to give N-[2-(3,4-dimethoxyphenyl)ethyl]-2-(p-toluidino)acetamide (18.6 g), mp 87° to 88.5° C.

1. temperatureAfter cooling
2. washthe solution was washed with a cooled 1 N sodium hydroxide solution and water
3. customdried
4. distillationThe solvent was distilled off
5. customthe oily residue was crystallized
6. additionby adding ether