反应详情

2-Chloroacrylonitrile (35 ml.) was added in portions over 15 minutes to a solution of chloroacetamidine hydrochloride (55 g.) and triethylamine (120 ml.) in EtOH (250 ml.) cooled to 10°. The temperature was allowed to rise to 40° over 1 hour. The mixture was cooled and filtered and the resulting solution evaporated in vacuo. The residue was taken up in EtOAc (600 ml.) from which a tar precipitated. The solution was treated with decolourising carbon, filtered and evaporated to give 4-amino-2-chloromethylpyrimidine as a brown solid.

1. temperaturecooled to 10°
2. temperatureThe mixture was cooled
3. filtrationfiltered
4. customthe resulting solution evaporated in vacuo
5. customprecipitated
6. additionThe solution was treated with decolourising carbon
7. filtrationfiltered
8. customevaporated