反应详情

To a solution of 5-[2-(amino)ethylthio]imidazo[1,2-a]pyridine (1.93 g, 10 mmoles) and triethylamine (1.53 ml, 11 mmoles) in methylene chloride (100 ml) was added ethanesulfonyl chloride (0.95 ml, 10 mmoles) at room temperature with stirring and the mixture was stirred at room temperature for 1 hour. The reaction mixture was washed in turn with an aqueous saturated sodium bicarbonate solution and water and dried over anhydrous magnesium sulfate, and then the solvent was distilled off. The residue was purified by column chromatography (eluent: ethanol/ethyl acetate=1:5) to obtain 2.23 g of the desired product (78.2%, colorless crystals).

1. stirringthe mixture was stirred at room temperature for 1 hour
2. washThe reaction mixture was washed in turn with an aqueous saturated sodium bicarbonate solution and water
3. dry with materialdried over anhydrous magnesium sulfate
4. distillationthe solvent was distilled off
5. customThe residue was purified by column chromatography (eluent: ethanol/ethyl acetate=1:5)