Ethyl bromoacetate → HCID 70478759, compound

HRID 544113Notes

Reaction equation

HRID 544113 reaction equation
[NH:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[OH:13].[H-].[Na+].Br[CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19]>CN(C)C=O>[CH2:21]([O:20][C:18](=[O:19])[CH2:17][O:13][C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=1[CH2:6][C:2]1[NH:1][CH:5]=[CH:4][N:3]=1)[CH3:22]

Participants

5

Reactant 3

HCID 7748Ethyl bromoacetateHCID 24758Sodium hydrideHCID 23289325HCID 23289325, compound

Product 1

HCID 70478759HCID 70478759, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Treatment of 2-(1-imidazolylmethyl)phenol with sodium hydride in dry N,N-dimethylformamide followed by ethyl bromoacetate as described in Example 11B gave 2-(1-imidazolylmethyl)phenoxyacetic acid ethyl ester as an oil which was used without further characterisation.

Sources & evidence

ORD record
ord-57ec012d3d9947f49746033814c9b9c2
Source dataset
uspto-grants-1984_05
Patent number
US04448781

Reaction notes

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