huagongshe.com
HRID544188

反应详情

EQUATION

反应方程式

HRID 544188 的结构方程式

REACTANTS

反应物

2
结构：O=C(Cl)C(=O)Cl
HCID65578

Ethanedioyl dichloride

C2Cl2O2

结构：CC(Oc1ccc(Oc2ccc(C(F)(F)F)cc2)cc1)C(=O)O
HCID181206

Trifop

C16H13F3O4

PRODUCTS

生成物

1
结构：CC(Oc1ccc(Oc2ccc(C(F)(F)F)cc2)cc1)C(=O)Cl
HCID12906015

2-{4-[4-(Trifluoromethyl)phenoxy]phenoxy}propanoyl chloride

C16H12ClF3O3

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CN(C)C=O
催化剂HCID6228

N,N-Dimethylformamide

C3H7NO

结构：CCOCC
溶剂HCID3283

Diethyl Ether

C4H10O

PROCEDURE

实验过程

Oxalyl chloride (1.56 g, 1.1 ml, 12.32 mmol) is added to a stirring solution of 2-[4-(4-trifluoromethylphenoxy)phenoxy]propionic acid (2.00 g, 6.16 mmol), dimethylformamide (DMF; 4 drops) and ether (50 ml). The mixture is stirred at RT for 3 hours. Insoluble material is filtered off and solvent is removed in vacuo to give 2-[4-(4-trifluoromethylphenoxy)phenoxy]propionic acid chloride.

WORKUP

后处理

  1. filtrationInsoluble material is filtered off
  2. customsolvent is removed in vacuo