反应详情

A mixture of 1-ethyl-6-chloro-7-(1-piperazinyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride 1.9 g (0.005 mole), 3-hydroxyphthalide 0.75 g (0.005 mole), triethylamine 0.5 g (0.005 mole) and DMF 10 ml was heated at 100°-110° C. for 8 hours under stirring. After cooling, the reaction mixture was evaporated under vacuum. The residue was dissolved in dichloromethane, washed with water and dried with anhydrous Na2SO4. After removing the solvent, the residue was recrystallized from a mixed solvent of DMF and ethanol to obtain 1.8 g (78%) of 1-ethyl-6-chloro-7-(4-phthalidyl-1-piperazinyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid. Colorless powders.

1. temperaturewas heated at 100°-110° C. for 8 hours
2. temperatureAfter cooling
3. customthe reaction mixture was evaporated under vacuum
4. dissolutionThe residue was dissolved in dichloromethane
5. washwashed with water
6. dry with materialdried with anhydrous Na2SO4
7. customAfter removing the solvent
8. customthe residue was recrystallized from a mixed solvent of DMF and ethanol