反应详情

温度

170 °C

A mixture of 1-ethyl-6-fluoro-7-chloro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (1.9 g), piperazine hexahydrate (15 g) and water (15 ml) was heated at 170° C. in a sealed tube for 16 hours. After evaporation of the solvent, the residue was acidified with diluted hydrochloric acid, heated at 100° C., and the hot solution was filtered. The filtrate was evaporated to dryness. The residue was dissolved in 10% sodium hydroxide and neutralized with acetic acid. The precipitate was collected, washed with water, dried, and recrystallized from ethanol to give 1-ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid as colorless powder.

1. customAfter evaporation of the solvent
2. temperatureheated at 100° C.
3. filtrationthe hot solution was filtered
4. customThe filtrate was evaporated to dryness
5. dissolutionThe residue was dissolved in 10% sodium hydroxide and neutralized with acetic acid
6. customThe precipitate was collected
7. washwashed with water
8. customdried
9. customrecrystallized from ethanol