反应详情

A mixture of 2,3-diaminopyridine (45 g), ethanol (500 ml), triethylamine (42 g) and benzyl bromide (70.5 g) was stirred at room temperature for 3 days. The solvent was evaporated in vacuo and the residue partitioned between chloroform (500 ml) and water (400 ml). The organic layer was eparated, filtered through a silica gel plug and evaporated in vacuo. The residue was triturated with hot chlorobutane to yield a brown powder.

1. customThe solvent was evaporated in vacuo
2. customthe residue partitioned between chloroform (500 ml) and water (400 ml)
3. filtrationfiltered through a silica gel plug
4. customevaporated in vacuo
5. customThe residue was triturated with hot chlorobutane
6. customto yield a brown powder