Hydrochloric Acid → Baxitozine

HRID 544508Notes

Reaction equation

HRID 544508 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13](=[O:20])[CH2:14][CH:15](O)[C:16]([OH:18])=[O:17])[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].Cl>C(O)(=O)C>[CH3:12][O:11][C:7]1[CH:6]=[C:5]([C:13](=[O:20])/[CH:14]=[CH:15]/[C:16]([OH:18])=[O:17])[CH:4]=[C:3]([O:2][CH3:1])[C:8]=1[O:9][CH3:10]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 30691792-Hydroxy-4-oxo-4-(3,4,5-trimethoxyphenyl)butanoic acid

Product 1

HCID 6366494Baxitozine

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

15.8 g of 4-(3,4,5-trimethoxyphenyl)-4-oxo-2-hydroxy butanoic acid obtainedin Example 3, 20 cc of acetic acid and 20 cc of concentrated hydrochloric acid (d-1.18) are heated for 2.5 hours under reflux.

Workup

  1. temperatureunder reflux

Sources & evidence

ORD record
ord-f53a38bf7b244fc5a65abee937ff5daf
Source dataset
uspto-grants-1984_05
Patent number
US04450292

Reaction notes

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