反应详情

To a solution of chloroacetamidine hydrochloride (11 g.) in EtOH (50 ml.) was added triethylamine (24 ml.) and 2-chloroacrylonitrile (6.8 ml.) and the mixture was heated under reflux for 10 minutes. The dark solution was evaporated to dryness in vacuo, the residue dissolved in EtOAc, the solution decolourised with carbon, filtered and the filtrate evaporated. Ether was added and the solution filtered to remove some insoluble material. Evaporation gave 4-amino-2-chloromethylpyrimidine (5 g.), m.p. 125°-128°.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 10 minutes
3. customThe dark solution was evaporated to dryness in vacuo
4. dissolutionthe residue dissolved in EtOAc
5. filtrationfiltered
6. customthe filtrate evaporated
7. additionEther was added
8. filtrationthe solution filtered
9. customto remove some insoluble material
10. customEvaporation