Propylamine → HCID 53782809, compound

HRID 544575Notes

Reaction equation

HRID 544575 reaction equation
[C:1]([NH:3][C:4]1[CH:9]=[CH:8][N:7]=[C:6]([S:10][CH3:11])[N:5]=1)#[N:2].[CH2:12]([NH2:15])[CH2:13][CH3:14]>C(#N)C>[CH2:12]([N:15]=[C:1]([NH2:2])[NH:3][C:4]1[CH:9]=[CH:8][N:7]=[C:6]([S:10][CH3:11])[N:5]=1)[CH2:13][CH3:14]

Participants

4

Reactant 2

HCID 7852PropylamineHCID 20458209Cyanamide, [2-(methylthio)-4-pyrimidinyl]-

Product 1

HCID 53782809HCID 53782809, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture of 4-cyanoamino-2-methylthiopyrimidine (0.83 g.) and n-propylamine (0.6 ml.) was heated under reflux in acetonitrile (20 ml.) for 1 hour. The solvent was evaporated in vacuo and the residue suspended in dilute aqueous sodium hydroxide. The solid was collected, washed with water and dried to give 4-(2-propylguanidino)-2-methylthiopyrimidine, m.p. 177°-178°.

Workup

  1. temperaturewas heated
  2. customThe solvent was evaporated in vacuo
  3. customThe solid was collected
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-c91a9f7f7ff34155bef03e449cc34e15
Source dataset
uspto-grants-1984_05
Patent number
US04451463

Reaction notes

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