Triphenylphosphine → 3-(5-Bromopentyl)-5-methylisoxazole

HRID 544629Notes

Reaction equation

HRID 544629 reaction equation
O[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]1[CH:11]=[C:10]([CH3:12])[O:9][N:8]=1.[Br:13]Br.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>>[Br:13][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]1[CH:11]=[C:10]([CH3:12])[O:9][N:8]=1

Participants

4

Reactant 3

HCID 11776TriphenylphosphineHCID 24408BromineHCID 133169773-(5-Hydroxypentyl)-5-methylisoxazole

Product 1

HCID 133169783-(5-Bromopentyl)-5-methylisoxazoleYield 77%

Procedure

3-(5-Bromopentyl)-5-methylisoxazole was prepared by reacting 3-(5-hydroxypentyl)-5-methylisoxazole with bromine and triphenylphosphine according to the procedure of part (f) above, and was obtained in 77% yield as an oil, b.p. 140°-150° C.(0.05 mm).

Workup

  1. customwas obtained in 77% yield as an oil, b.p. 140°-150° C.(0.05 mm)

Sources & evidence

ORD record
ord-fce2d7781be84cbf98c0333fd12b0113
Source dataset
uspto-grants-1984_05
Patent number
US04451476

Reaction notes

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