Methylamine → HCID 24985575, compound

HRID 544929Notes

Reaction equation

HRID 544929 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:12][C:11]([C:13]([NH:15][C:16]3[CH:17]=[C:18]([CH:22]=[CH:23][C:24]=3[CH3:25])[C:19](O)=[O:20])=[O:14])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[CH3:26][NH2:27]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:12][C:11]([C:13]([NH:15][C:16]3[CH:17]=[C:18]([C:19](=[O:20])[NH:27][CH3:26])[CH:22]=[CH:23][C:24]=3[CH3:25])=[O:14])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 45429161HCID 45429161, compound

Product 1

HCID 24985575HCID 24985575, compoundYield 73%

Procedure

The title compound (Example 186) was prepared by reacting 3-(5-(4-chlorophenyl)thiophene-2-carboxamido)-4-methylbenzoic acid C with methylamine using the method described in Example 128 to afford a white solid in 73% yield. HPLC Ret. Time=3.51 min, LCMS [M+H]+ 385.08.

Workup

  1. customto afford a white solid in 73% yield

Sources & evidence

ORD record
ord-c94a4516294c4ddcb676ab6693eaac5b
Source dataset
uspto-grants-2011_05
Patent number
US07935696B2

Reaction notes

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