Guanidine Hydrochloride → HCID 59851096, compound

HRID 545057Notes

Reaction equation

HRID 545057 reaction equation
C([O-])(O)=O.[Na+].Cl.[NH2:7][C:8]([NH2:10])=[NH:9].[Cl:11][C:12]1[CH:13]=[CH:14][C:15]2[C:21](=O)[C:20](=[CH:23]N(C)C)[CH2:19][C:18](=[O:27])[NH:17][C:16]=2[CH:28]=1>>[NH2:9][C:8]1[N:10]=[CH:23][C:20]2[CH2:19][C:18](=[O:27])[NH:17][C:16]3[CH:28]=[C:12]([Cl:11])[CH:13]=[CH:14][C:15]=3[C:21]=2[N:7]=1

Participants

4

Reactant 3

HCID 5742Guanidine HydrochlorideHCID 516892Sodium BicarbonateHCID 669348778-chloro-4-dimethylaminomethylene-3,4-dihydro-1H-benzo[b]azepine-2,5-dione

Product 1

HCID 59851096HCID 59851096, compound

Procedure

In a manner similar to that described for method I (NaHCO3 used instead of K2CO3), guanidine hydrochloride and 8-chloro-4-((dimethylamino)methylene)-3,4-dihydro-1H-benzo[b]azepine-2,5-dione (v-j) were converted to I-23 (72%): HRMS Calcd. for C12H9ClN4O: 261.0543, Found 261.0543.

Sources & evidence

ORD record
ord-37b5b01f874d4104a5eeea4e40169ad2
Source dataset
uspto-grants-2011_05
Patent number
US07935694B2

Reaction notes

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