反应详情

A stirred mixture of 2-nitrophenol (13.9 g, 0.10 mol), benzyl bromide (12.0 ml, 0.10 mol) and anhydrous potassium carbonate (30 g, 0.22 mol) in acetone (200 ml) is heated under reflux for 16 hours, cooled, poured onto ice-dilute hydrochloric acid, and extracted with dichloromethane. The extract is dried and evaporated and the residue is crystallized from ether-hexane as pale crystals, m.p. <50° C.

1. temperatureis heated
2. temperatureunder reflux for 16 hours
3. temperaturecooled
4. additionpoured onto ice-dilute hydrochloric acid
5. extractionextracted with dichloromethane
6. customThe extract is dried
7. customevaporated
8. customthe residue is crystallized from ether-hexane as pale crystals, m.p. <50° C.