反应详情

Wet Raney nickel is added in portions to a stirred refluxing solution of 7-(benzyloxy)-3-methylthio)indole (4.0 g, 14.9 mmol) in ethyl acetate (100 ml) and ethanol (60 ml) until all the starting material has been consumed (by RP HPLC). The mixture is filtered, the filtrate evaporated and the residue chromatographed on silica in ethyl acetate-hexane (1:8) to give a pale oil.

1. customhas been consumed (by RP HPLC)
2. filtrationThe mixture is filtered
3. customthe filtrate evaporated
4. customthe residue chromatographed on silica in ethyl acetate-hexane (1:8)
5. customto give a pale oil