反应详情

A mixture of 1-benzyl-4-(4-cyanobutyl)piperidine (2.20 g), potassium carbonate (3.56 g) and hydroxylamine hydrochloride (2.39 g) was heated under reflux for 20 hours. After cooling, the mixture was filtered and evaporated in vacuo. The residue was dissolved in ether, filtered and recrystallized to afford 5-(1-benzylpiperidin-4-yl)-1-hydroxyiminopentylamine (1.56 g).

1. temperaturewas heated
2. temperatureunder reflux for 20 hours
3. temperatureAfter cooling
4. filtrationthe mixture was filtered
5. customevaporated in vacuo
6. dissolutionThe residue was dissolved in ether
7. filtrationfiltered
8. customrecrystallized