Sodium Hydroxide → HCID 72234595, compound

HRID 545583Notes

Reaction equation

HRID 545583 reaction equation
[CH:1]([C:3]1[CH:4]=[C:5]2[C:13](=[CH:14][CH:15]=1)[NH:12][C:11]1[CH2:10][CH2:9][CH:8]([NH:16][C:17]([CH:19]3[CH2:21][CH2:20]3)=[O:18])[CH2:7][C:6]2=1)=O.Cl.[O:23]([NH2:25])[CH3:24].[OH-].[Na+]>>[CH3:24][O:23][N:25]=[CH:1][C:3]1[CH:4]=[C:5]2[C:13](=[CH:14][CH:15]=1)[NH:12][C:11]1[CH2:10][CH2:9][CH:8]([NH:16][C:17]([CH:19]3[CH2:21][CH2:20]3)=[O:18])[CH2:7][C:6]2=1

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 521874O-Methylhydroxylamine hydrochlorideHCID 59161282HCID 59161282, compound

Product 1

HCID 72234595HCID 72234595, compound

Procedure

Prepare the title compound from cyclopropanecarboxylic acid(6-formyl-2,3,4,9-tetrahydro-1H-carbazol-3-yl)-amide (Preparation 72) (6.50 g, 57.3 mmol) methoxylamine hydrochloride (4.81 g, 57.6 mmol) and sodium hydroxide (1.84 g, 46.0 mmol), by essentially following procedures as described in Example 202 to obtain 6.00 g (84%) of product. MS (ES): m/z 312 (M+1).

Sources & evidence

ORD record
ord-c3166b255cb8409c97c3f8a7ec3e17b4
Source dataset
uspto-grants-2011_05
Patent number
US07935722B2

Reaction notes

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