反应详情

温度

55 °C

To a solution of 4-hydroxy-benzoic acid tert-butoxycarbonylmethyl ester 15 (18 grams, 71.42 mmol) in tetrahydrofuran (100 mL) is added 10% lithium hydroxide solution (35 mL). The mixture is heated at 50-60° C. for 1 hour. The reaction mass is cooled to room temperature, and the pH is adjusted to 4 with dilute acetic acid. The organic phase is separated and distilled to give crude 16, which can be purified in appropriate solvent.

1. temperatureThe reaction mass is cooled to room temperature
2. customThe organic phase is separated
3. distillationdistilled
4. customto give crude 16, which
5. customcan be purified in appropriate solvent