反应详情

Methyl 5-chloro-6-fluoroindole-2-carboxylate (461 mg) was dissolved in a mixed solvent of tetrahydrofuran (15 ml), methanol (10 ml) and water (10 ml), lithium hydroxide (283 mg) was added at room temperature, and the mixture was stirred for 4 hours. The solvent was distilled off under reduced pressure, and 1N hydrochloric acid was added to the residue to weakly acidify it. The resultant powder was collected by filtration and dried to obtain the title compound (422 mg) as colorless powder.

1. additionwas added at room temperature
2. distillationThe solvent was distilled off under reduced pressure, and 1N hydrochloric acid
3. additionwas added to the residue
4. filtrationThe resultant powder was collected by filtration
5. customdried