反应详情

Benzenesulfonamide (638 mg) and 4,5-bis(bromo-methyl)thiazole (1.10 g) were dissolved in dimethylformamide (10 ml), 60% sodium hydride in oil (357 mg) was added at a time, and the mixture was stirred at room temperature for 3 hours. Water and dichloromethane were added to conduct liquid separation. After the resultant oil layer was dried over anhydrous sodium sulfate, the solvent was distilled off, and the residue was purified by column chromatography on silica gel (dichloromethane:ethylacetate=9:1) to obtain the title compound (137 mg) as colorless powder.

1. customliquid separation
2. dry with materialAfter the resultant oil layer was dried over anhydrous sodium sulfate
3. distillationthe solvent was distilled off
4. customthe residue was purified by column chromatography on silica gel (dichloromethane:ethylacetate=9:1)