反应详情

A mixture of 5-(benzenesulfonyl)-4,6-dihydro-5H-pyrrolo[3,4-d]thiazole (800 mg), phenol (800 μl) and 47% hydrobromic acid (5.00 ml) was heated under reflux for 2 hours. After the reaction mixture was cooled to room temperature, ethyl acetate and water were added to conduct liquid separation. The resultant water layer was concentrated under reduced pressure. Ethyl acetate was added to the residue, colorless powder deposited was collected by filtration to obtain the title compound (521 mg).

1. temperaturewas heated
2. temperatureunder reflux for 2 hours
3. customliquid separation
4. concentrationThe resultant water layer was concentrated under reduced pressure
5. additionEthyl acetate was added to the residue, colorless powder
6. filtrationdeposited was collected by filtration