反应详情

1,2-Epoxy-4-methoxycarbonylcyclopentane (37.7 g) was dissolved in a mixed solvent of tetrahydrofuran (500 ml) and water (500 ml), and sulfuric acid (13.3 ml) was added dropwise under ice cooling to stir the mixture at room temperature for 4 hours. Sodium carbonate and sodium hydrogencarbonate were added to the reaction mixture to make the mixture neutral or weakly alkaline, and the solvent was distilled off under reduced pressure. The residue was extracted with dichloromethane and ethyl acetate, insoluble matter was removed by filtration, and the filtrate was concentrated under reduced pressure to obtain the title compound (35.5 g) as a pale yellow oil.

1. additionwas added dropwise under ice cooling
2. distillationweakly alkaline, and the solvent was distilled off under reduced pressure
3. extractionThe residue was extracted with dichloromethane and ethyl acetate, insoluble matter
4. customwas removed by filtration
5. concentrationthe filtrate was concentrated under reduced pressure