Hydrochloric Acid → HCID 68909232, compound

HRID 546483Notes

Reaction equation

HRID 546483 reaction equation
Cl.C(O)C.C(OC([NH:12][C@H:13]1[CH2:18][C@H:17]([C:19]([OH:22])([CH3:21])[CH3:20])[CH2:16][CH2:15][C@H:14]1[NH:23][C:24]([C:26]1[NH:27][C:28]2[C:33]([CH:34]=1)=[CH:32][C:31]([Cl:35])=[CH:30][CH:29]=2)=[O:25])=O)(C)(C)C>O1CCOCC1>[ClH:35].[Cl:35][C:31]1[CH:32]=[C:33]2[C:28](=[CH:29][CH:30]=1)[NH:27][C:26]([C:24]([NH:23][C@@H:14]1[CH2:15][CH2:16][C@@H:17]([C:19]([OH:22])([CH3:21])[CH3:20])[CH2:18][C@@H:13]1[NH2:12])=[O:25])=[CH:34]2

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 68907678HCID 68907678, compound

Product 1

HCID 68909232HCID 68909232, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A 4N hydrogen chloride solution in dioxane (10 ml) was added to an ethanol solution (5 ml) of (1R*,2S*,4R*)-N2-tert-butoxycarbonyl-N1-[(5-Chloroindol-2-yl)carbonyl]-4-(1-hydroxy-1-methylethyl)-1,2-cyclohexanediamine, and the mixture was stirred at room temperature for 12 hours. The solvent was distilled off under reduced pressure to obtain the title compound (100 mg) as a colorless oil.

Workup

  1. distillationThe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-3eca27faedd04cfd8cac5bdeffff19f1
Source dataset
uspto-grants-2011_05
Patent number
US07935824B2

Reaction notes

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