Hydrochloric Acid → HCID 58822086, compound

HRID 546525Notes

Reaction equation

HRID 546525 reaction equation
C([O:5][C:6]([NH:8][C@@H:9]1[CH2:14][CH2:13][C@H:12]([C:15]([O:17][CH3:18])=[O:16])[CH2:11][C@@H:10]1[NH:19][C:20]([C:22]1[NH:23][C:24]2[C:29]([CH:30]=1)=[CH:28][C:27]([Cl:31])=[CH:26][CH:25]=2)=[O:21])=O)(C)(C)C.Cl.[CH3:33][N:34]1[CH2:39][CH2:38][C:37]2[N:40]=[C:41](C([O-])=O)[S:42][C:36]=2[CH2:35]1.[Li+]>C(O)C>[Cl:31][C:27]1[CH:28]=[C:29]2[C:24](=[CH:25][CH:26]=1)[NH:23][C:22]([C:20]([NH:19][C@H:10]1[CH2:11][C@@H:12]([C:15]([O:17][CH3:18])=[O:16])[CH2:13][CH2:14][C@H:9]1[NH:8][C:6]([C:41]1[S:42][C:36]3[CH2:35][N:34]([CH3:33])[CH2:39][CH2:38][C:37]=3[N:40]=1)=[O:5])=[O:21])=[CH:30]2

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 23704331Lithium 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylateHCID 58822090HCID 58822090, compound

Product 1

HCID 58822086HCID 58822086, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

(1R*,2S*,4S*)-N1-tert-Butoxycarbonyl-N2-[(5-chloroindol-2-yl)carbonyl]-4-methoxycarbonyl-1,2-cyclohexanediamine was treated with a saturated ethanol solution of hydrochloric acid and then condensed with lithium 5-methyl-4,5,6,7-tetrahydro-thiazolo[5,4-c]-pyridine-2-carboxylate in a similar manner to Example 118 to obtain the title compound.

Sources & evidence

ORD record
ord-f08be433e2094336b93ed5c134fc629d
Source dataset
uspto-grants-2011_05
Patent number
US07935824B2

Reaction notes

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