1-(3-Nitrobenzoyl)pyrrolidine → 3-(Pyrrolidin-1-ylcarbonyl)aniline

HRID 546619Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 546619
[N+:1]([C:4]1[CH:5]=[C:6]([CH:14]=[CH:15][CH:16]=1)[C:7]([N:9]1[CH2:13][CH2:12][CH2:11][CH2:10]1)=[O:8])([O-])=O.C([O-])=O.[NH4+]>CO.[Pd]>[N:9]1([C:7]([C:6]2[CH:5]=[C:4]([CH:16]=[CH:15][CH:14]=2)[NH2:1])=[O:8])[CH2:10][CH2:11][CH2:12][CH2:13]1

Komponenten

5

Edukt 2

HCID 7115231-(3-Nitrobenzoyl)pyrrolidineHCID 2723923Ammonium formate

Produkt 1

HCID 166429413-(Pyrrolidin-1-ylcarbonyl)anilineAusbeute 67,9 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 1.91 g of 1-(3-nitrobenzoyl)pyrrolidine obtained in stage a) below in 50 mL of methanol are added, under argon, 4.38 g of ammonium formate and 9 mg of 10% palladium-on-charcoal. The reaction mixture is stirred at room temperature for 1 hour and then filtered through Celite and concentrated under reduced pressure. The residue is taken up in water and extracted with ethyl acetate. The organic phase is then washed with saturated sodium chloride solution, dried over magnesium sulphate, filtered and concentrated under reduced pressure to give 1.12 g of 3-(pyrrolidin-1-ylcarbonyl)aniline, the characteristics of which are as follows:

Aufarbeitung

  1. filtrationfiltered through Celite
  2. concentrationconcentrated under reduced pressure
  3. extractionextracted with ethyl acetate
  4. washThe organic phase is then washed with saturated sodium chloride solution
  5. dry with materialdried over magnesium sulphate
  6. filtrationfiltered
  7. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-9f4ab12d7f1c4208802dfb8db527bf64
Quelldatensatz
uspto-grants-2011_05
Patentnummer
US07935819B2

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