反应详情

To a solution of 1.91 g of 1-(3-nitrobenzoyl)pyrrolidine obtained in stage a) below in 50 mL of methanol are added, under argon, 4.38 g of ammonium formate and 9 mg of 10% palladium-on-charcoal. The reaction mixture is stirred at room temperature for 1 hour and then filtered through Celite and concentrated under reduced pressure. The residue is taken up in water and extracted with ethyl acetate. The organic phase is then washed with saturated sodium chloride solution, dried over magnesium sulphate, filtered and concentrated under reduced pressure to give 1.12 g of 3-(pyrrolidin-1-ylcarbonyl)aniline, the characteristics of which are as follows:

1. filtrationfiltered through Celite
2. concentrationconcentrated under reduced pressure
3. extractionextracted with ethyl acetate
4. washThe organic phase is then washed with saturated sodium chloride solution
5. dry with materialdried over magnesium sulphate
6. filtrationfiltered
7. concentrationconcentrated under reduced pressure