Hydrogen Bromide → HCID 14719547, compound

HRID 54667Notes

Reaction equation

HRID 54667 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH2:9][NH:8][CH2:7][CH:6]2[C:13]1[CH:18]=[CH:17][C:16]([O:19]C)=[C:15]([O:21]C)[CH:14]=1.[BrH:23]>>[BrH:23].[OH:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH2:9][NH:8][CH2:7][CH:6]2[C:13]1[CH:18]=[CH:17][C:16]([OH:19])=[C:15]([OH:21])[CH:14]=1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 147195466-Methoxy-4-(3,4-dimethoxyphenyl)-1,2,3,4-tetrahydroisoquinoline

Product 1

HCID 14719547HCID 14719547, compound

Procedure

To 790 mg of 6-methoxy-4-(3,4-dimethoxyphenyl)-1,2,3,4-tetrahydroisoquinoline, was added 16 ml of 48% hydrobromic acid, and the mixture was heated under reflux for 3 hours under an argon stream. The reaction solution was cooled, and precipitates which separated out were collected by filtration, giving 630 mg of 6-hydroxy-4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinoline hydrobromide.

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 3 hours under an argon stream
  3. temperatureThe reaction solution was cooled
  4. customprecipitates which
  5. customseparated out
  6. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-a0f164230cc140298893bee2f8c9c1f3
Source dataset
uspto-grants-1997_04
Patent number
US05623074

Reaction notes

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