反应详情

Chloroacetone (1.83 ml), cesium carbonate (7.99 g) and potassium iodide (254 mg) were added to a solution of N-(2,6-difluoropyridin-3-yl)formamide (2.42 g) in N,N-dimethylformamide (50 ml), and the reaction solution was stirred at room temperature for two hours. Ethyl acetate and water were added to the reaction solution, and the organic layer was separated. The resulting organic layer was washed with brine and then dried over anhydrous sodium sulfate. The drying agent was separated by filtration, and then the organic layer was concentrated under reduced pressure. The residue was purified by silica gel column chromatography to obtain the title compound (2.52 g). The property values of the compound are as follows.

1. customthe organic layer was separated
2. washThe resulting organic layer was washed with brine
3. dry with materialdried over anhydrous sodium sulfate
4. customThe drying agent was separated by filtration
5. concentrationthe organic layer was concentrated under reduced pressure
6. customThe residue was purified by silica gel column chromatography