Hydrochloric Acid → HCID 67711955, compound

HRID 54693Notes

Reaction equation

HRID 54693 reaction equation
Br.[NH2:2][C:3]1[N:4]([CH2:20][C:21](=O)[C:22]([CH3:25])([CH3:24])[CH3:23])[C:5]2[CH:19]=[CH:18][CH:17]=[CH:16][C:6]=2[N+:7]=1[CH2:8][CH2:9][N:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1.[OH-].[NH4+].[ClH:29]>>[ClH:29].[C:22]([C:21]1[N:2]=[C:3]2[N:4]([CH:20]=1)[C:5]1[CH:19]=[CH:18][CH:17]=[CH:16][C:6]=1[N:7]2[CH2:8][CH2:9][N:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1)([CH3:25])([CH3:24])[CH3:23]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14923Ammonium HydroxideHCID 178419540HCID 178419540, compound

Product 1

HCID 67711955HCID 67711955, compound

Procedure

The hydrobromide obtained in Step A is heated at reflux in concentrated hydrochloric acid for 30 minutes. The solution is cooled and neutralised with an aqueous ammonium hydroxide solution. The reaction mixture is extracted with benzene and the extract is dried over sodium sulfate. Subsequently, pass through a stream of gaseous hydrochloric acid until acidity. The resulting precipitate is filtered and recrystallised from ethanol.

Workup

  1. temperatureThe solution is cooled
  2. extractionThe reaction mixture is extracted with benzene
  3. dry with materialthe extract is dried over sodium sulfate
  4. filtrationThe resulting precipitate is filtered
  5. customrecrystallised from ethanol

Sources & evidence

ORD record
ord-85242c788d704bda9f32d11196169e8c
Source dataset
uspto-grants-1997_04
Patent number
US05623073

Reaction notes

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