反应详情

温度

150 °C

Toluene (2.0 mL) and water (0.20 mL) were added to t-butyl-(1-{2-[4-(1-ethyl-1-{4-[4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl]-3-methyl-phenyl}-propyl)-2-methyl-phenyl]-ethyl}-2,2-dimethyl-propoxy)dimethylsilane (Example 23-(1); 50.0 mg, 0.0824 mmol), (S)-t-butoxycarbonylamino-(4-chloro-phenyl)-acetic acid methyl ester (Example 166-(1); 37.0 mg, 0.123 mmol), palladium (II) acetate (1.9 mg, 0.00846 mmol), 2-dicyclohexylphosphino-2′,6′-dimethoxy-1,1′-biphenyl (6.8 mg, 0.0166 mmol) and potassium phosphate (52.0 mg, 0.245 mmol). After replacement with nitrogen, the mixture was stirred with microwave heating at 150° C. for five minutes. The reaction mixture was purified by silica gel chromatography (hexane:ethyl acetate=100:0 to 70:30) to give the target compound as a colorless oil (56.4 mg, 92%).

1. customThe reaction mixture was purified by silica gel chromatography (hexane:ethyl acetate=100:0 to 70:30)