反应详情

温度

105 °C

Ethyl 4chlorobutyrate (0.154 ml, 1.1 mmol) was added to a mixture of 4-(4-chloro-2-fluoroanilino)-7-hydroxy-6-methoxyquinazoline (319.5 mg, 1 mmol), (prepared as described for the starting material in Example 2), and anhydrous potassium carbonate (690 mg, 5 mmol) in DMF (10 ml). The mixture was stirred and heated at 105° C. for 4 hours then allowed to cool. The mixture was diluted with methylene chloride and the insolubles were removed by filtration. The solvent was removed from the filtrate by evaporation and the residue was purified by column chromatography eluting with methylene chloride/methanol/aqueous ammonia (1008/1). The purified product was triturated with ether collected by filtration and dried to give 4-(4-chloro-2-fluoroanilino)-7-(3-ethoxycarbonylpropoxy)-6-methoxyquinazoline (230 mg, 53%).

1. custom(prepared
2. temperatureto cool
3. customthe insolubles were removed by filtration
4. customThe solvent was removed from the filtrate by evaporation
5. customthe residue was purified by column chromatography
6. washeluting with methylene chloride/methanol/aqueous ammonia (1008/1)
7. customThe purified product was triturated with ether
8. filtrationcollected by filtration
9. customdried