Water → HCID 689757, compound

HRID 547242Notes

Reaction equation

HRID 547242 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8].[Cl-].[Li+].[C:11](Cl)(=[O:21])[C:12]1[CH:20]=[CH:19][CH:18]=[C:14]([C:15](Cl)=[O:16])[CH:13]=1.[OH2:23]>CN1C(=O)CCC1>[OH:8][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[NH:1][C:11](=[O:21])[C:12]1[CH:20]=[CH:19][CH:18]=[C:14]([C:15]([NH:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=2[OH:23])=[O:16])[CH:13]=1

Participants

6

Reactant 4

HCID 962WaterHCID 58012-AminophenolHCID 7451Isophthaloyl chlorideHCID 433294Lithium Chloride

Product 1

HCID 689757HCID 689757, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

In 260 mL of NMP were dissolved 27.548 g of o-aminophenol and 11.484 g of lithium chloride. To the solution was added 25 g of isophthaloyl chloride under ice-cooling, and the solution was further stirred at room temperature overnight. The reaction mixture was then poured into water, and the precipitation was filtered and washed with water. The obtained precipitation was dissolved in 500 mL of tetrahydrofuran again and dried over magnesium sulfate. The solvent was then evaporated off under a reduced pressure to obtain 40 g of N,N′-di(2-hydroxyphenyl)isophthalamide.

Workup

  1. temperaturecooling
  2. customthe precipitation
  3. filtrationwas filtered
  4. washwashed with water
  5. customThe obtained precipitation
  6. dissolutionwas dissolved in 500 mL of tetrahydrofuran again
  7. dry with materialdried over magnesium sulfate
  8. customThe solvent was then evaporated off under a reduced pressure

Sources & evidence

ORD record
ord-c9c586e090e54369ac5af4d2b7fd9c24
Source dataset
uspto-grants-2011_05
Patent number
US07939241B2

Reaction notes

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