反应详情

温度

2.5 °C

trans-(4-Hydroxy-cyclohexyl)-acetic acid methyl ester (500 mg, 2.90 mmol) were dissolved in 1.5 ml DMF and cooled to 0-5° C. Sodium hydride (190 mg, 4.35 mmol, 55%) and iodomethane (3.62 ml, 23.2 mmol) were added and the reaction mixture stirred for 4 hours at 0-5° C. The reaction mixture was quenched with saturated NaHCO3-solution and extracted with dichloromethane. The organic extract was washed with brine, dried with sodium sulfate, filtered and evaporated. The crude product (561 mg, quant.) was obtained as a colourless oil and used without any further purification for the next step.

1. customThe reaction mixture was quenched with saturated NaHCO3-solution
2. extractionextracted with dichloromethane
3. extractionThe organic extract
4. washwas washed with brine
5. dry with materialdried with sodium sulfate
6. filtrationfiltered
7. customevaporated