反应详情

温度

140 °C

Tetrakistriphenylphosphine palladium (0.15 g) was added to a mixed solution of 0.50 g of 5-(2-pyridyl)-3-bromo-2-methoxypyridine, 0.42 g of 2-(2-cyanophenyl)-1,3,2-dioxaborinate, 0.82 g of cesium carbonate and 20 ml of dimethylformamide and the mixture was stirred at 140° C. in a nitrogen atmosphere for 5 hours. After cooling to room temperature, ethyl acetate was added thereto, the mixture was washed with water and a saturated saline solution and dried over magnesium sulfate. The solvent was concentrated in vacuo and the residue was purified by a silica gel column chromatography (ethyl acetate:hexane=1:3) to give 0.36 of the title compound as pale yellow powder.

1. temperatureAfter cooling to room temperature
2. washthe mixture was washed with water
3. dry with materiala saturated saline solution and dried over magnesium sulfate
4. concentrationThe solvent was concentrated in vacuo
5. customthe residue was purified by a silica gel column chromatography (ethyl acetate:hexane=1:3)