反应详情

温度

100 °C

5 ml of a dimethylformamide solution containing 0.26 g of 3-(2-pyridyl)-5-phenyl-2(1H)-pyridone was incorporated with 0.04 g of sodium hydride. After 15 minutes, the solution was further incorporated with 0.15 g of 2-fluorobenzonitrile and 0.10 g of cuprous iodide, and vigorously stirred at 100° C. for 2 hours. The solution was cooled to room temperature, diluted with water, and extracted with ethyl acetate. The organic layer was washed with water and then saturated saline water, and dried by magnesium sulfate anhydride. The solvent was distilled off under a vacuum. The residue was refined by silica gel chromatography (ethyl acetate/hexane=1:2), to obtain 0.03 g of the light yellow, powdery subject compound.

1. temperatureThe solution was cooled to room temperature
2. extractionextracted with ethyl acetate
3. washThe organic layer was washed with water
4. dry with materialsaturated saline water, and dried by magnesium sulfate anhydride
5. distillationThe solvent was distilled off under a vacuum
6. customto obtain 0.03 g of the light yellow, powdery subject compound