Hydrochloric Acid → HCID 67195616, compound

HRID 547901Notes

Reaction equation

HRID 547901 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[CH:16]=[N:17][C:18]([NH2:22])=[C:19]([CH3:21])[CH:20]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:23]>O1CCOCC1>[ClH:23].[ClH:23].[CH3:21][C:19]1[C:18]([NH2:22])=[N:17][CH:16]=[C:15]([NH:14][CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[CH:20]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67195457HCID 67195457, compound

Product 1

HCID 67195616HCID 67195616, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

A solution of 4-(6-amino-5-methyl-pyridin-3-ylamino)-piperidine-1-carboxylic acid tert-butyl ester (2.84 g, 9.27 mmol) in dioxane (30 mL) and 4 M HCl in dioxane (20 mL) was stirred at rt for 2 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 207.1 [M+H]+.

Workup

  1. customThe solvent was removed under reduced pressure
  2. customthe crude product used in the consecutive step without further purification

Sources & evidence

ORD record
ord-af5e8ca015a34fd5bbc4b568972abce9
Source dataset
uspto-grants-2011_05
Patent number
US07939661B2

Reaction notes

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