Hydrochloric Acid → HCID 67194713, compound

HRID 547907Notes

Reaction equation

HRID 547907 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[CH:20]=[CH:19][N:18]=[C:17]([CH3:21])[CH:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:22]>O1CCOCC1>[ClH:22].[ClH:22].[CH3:21][C:17]1[CH:16]=[C:15]([NH:14][CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[CH:20]=[CH:19][N:18]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67196123HCID 67196123, compound

Product 1

HCID 67194713HCID 67194713, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

A solution of 4-(2-methyl-pyridin-4-ylamino)-piperidine-1-carboxylic acid tert-butyl ester (1.31 g, 4.50 mmol) in dioxane (20 mL) and 4 M HCl in dioxane (20 mL) was stirred at rt for 2 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 192.1 [M+H]+.

Workup

  1. customThe solvent was removed under reduced pressure
  2. customthe crude product used in the consecutive step without further purification

Sources & evidence

ORD record
ord-529d928633c046148df89fc8a92a9f17
Source dataset
uspto-grants-2011_05
Patent number
US07939661B2

Reaction notes

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