4-Hydroxybenzenesulfonic acid → 4-(Chlorosulfonyl)phenyl acetate

HRID 548079Notes

Reaction equation

HRID 548079 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([OH:11])(=[O:10])=O)=[CH:4][CH:3]=1.C(Cl)(=O)C([Cl:15])=O.[C:18]([O:21]C(=O)C)(=O)[CH3:19]>C(O)(=O)C.CN(C=O)C>[C:18]([O:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([Cl:15])(=[O:10])=[O:11])=[CH:6][CH:7]=1)(=[O:21])[CH3:19]

Participants

6

Reactant 3

HCID 47654-Hydroxybenzenesulfonic acidHCID 7918Acetic AnhydrideHCID 65578Oxalyl chloride

Product 1

HCID 129257104-(Chlorosulfonyl)phenyl acetateYield 83%

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 176Acetic AcidSolvent

Procedure

6.285 g (36.08 mmol) of 4-hydroxybenzenesulfonic acid was dissolved in a mixture of 30 mL of acetic anhydride and 15 mL of acetic acid and refluxed for 6 hours. The volatiles were evaporated and placed under high vacuum overnight. The resulting crude product was dissolved in 100 mL of DCM and treated with 4.72 mL of oxalyl chloride (54.12 mmol) and 139 μL of DMF (1.804 mmol) at 0° C. Stirring was continued until gas evolution ceased then the reaction was concentrated and re-dissolved in EtOAc. The organic layer was washed twice with 2 N H2SO4, and dried with brine and MgSO4. concentration gave 7.067 g of 4-(chlorosulfonyl)phenyl acetate as a dark thick oil that eventually solidified (83% yield over two steps).

Workup

  1. temperaturerefluxed for 6 hours
  2. customThe volatiles were evaporated
  3. customplaced under high vacuum overnight
  4. dissolutionThe resulting crude product was dissolved in 100 mL of DCM
  5. concentrationthe reaction was concentrated
  6. dissolutionre-dissolved in EtOAc
  7. washThe organic layer was washed twice with 2 N H2SO4
  8. dry with materialdried with brine and MgSO4
  9. concentrationconcentration

Sources & evidence

ORD record
ord-b9587f49887b419990d29c2de45853d0
Source dataset
uspto-grants-2011_05
Patent number
US07939671B2

Reaction notes

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