反应详情

温度

0 °C

A slurry of 3.15 g of product from Example 283 and 1.35 g of potassium carbonate in 15 ml of tetrahydrofuran at 0° C., under argon, is treated with 2.11 g of p-nitrobenzyl chloroformate and the reaction is stirred vigorously at 0° C. for 4 hours. The reaction mixture is diluted with 100 ml of water, extracted with 3×100 ml of ethyl acetate, dried, concentrated in vacuo and purified by chromatography (Silica Gel: 5-50% ethyl acetate/hexane) to give 3.49 g of the desired product.

1. extractionextracted with 3×100 ml of ethyl acetate
2. customdried
3. concentrationconcentrated in vacuo
4. custompurified by chromatography (Silica Gel: 5-50% ethyl acetate/hexane)